Scott IA, Hilmer SN, Reeve E, Potter K, Couteur DL et al (2015) Reducing inappropriate
polypharmacy: the process of deprescribing. JAMA Intern Med 175(5):827–834. https://doi.
org/10.1001/jamainternmed.2015.0324
Sender R, Fuchs S, Milo R (2016) Are we really vastly outnumbered? Revisiting the ratio of
bacterial to host cells in humans. Cell 164(3):337–340
Serra-Prat M, Mans E, Palomera E, Clave P (2013) Gastrointestinal peptides, gastrointestinal
motility, and anorexia of aging in frail elderly persons. Neurogastroenterol Motil 25(4):291–
e245
Sharma M, Loh KP, Nightingale G, Mohile SG, Holmes HM (2016) Polypharmacy and potentially
inappropriate medication use in geriatric oncology. J Geriatr Oncol 7(5):346–353. https://doi.
org/10.1016/j.jgo.2016.07.010
Shehab-Eldin W, Shaaban M, Atia AS, Zewain SK (2020) The association between thyroid
function and nutritional status in patients with end-stage renal disease on hemodialysis. Alex
J Med 56(1):220–225
Skinner MH, Kuan H-Y, Skerjanec A, Seger ME, Heathman M, O’Bian L, Reddy S, Knadler MP
(2003) Effect of age on the pharmacokinetics of duloxetine in women. Br J Clin Pharmacol
57(1):54–61
Sparkman NL, Li M (2012) Drug–drug conditioning between citalopram and haloperidol or
olanzapine in a conditioned avoidance response model: implications for polypharmacy in
schizophrenia. Behav Pharmacol 23(7):658–668
Stout SM, Nielsen J, Bleske BE, Shea M, Brook R, Kerber K, Welage LS (2010) The impact of
paroxetine coadministration on stereospecific carvedilol pharmacokinetics. J Cardiovasc
Pharmacol Ther 15(4):373–379
Streeter AJ, Faria EC (2017) Analysis of the variability of the pharmacokinetics of multiple drugs in
young adult and elderly subjects and its implication for acceptable daily exposures and cleaning
validation limits. Int J Hyg Environ Health 220(4):659–672
Szalach LP, Lisowska KA, Cubala WJ (2019) The influence of antidepressants on the immune
system. Arch Immunol Ther Exp 67:143–151
Taylor WD (2015) Should antidepressant medication be used in the elderly? Expert Rev Neurother
15(9):961–963
Telessy IG, Buttar HS (2017) Obesity related alterations in pharmacokinetics and pharmacodynam-
ics of drugs: emerging clinical implications in obese patients—part II. Adipobiology 9:31–40
Tiihonen K, Ouweh AC, Rautonen N (2010) Human intestinal microbiota and healthy ageing.
Ageing Res Rev 9(2):107–116
Timmer CJ, Sitsen JM, Delbressine LP (2000) Clinical pharmacokinetics of mirtazepine. Clin
Pharmacokinet 38(6):461–474
Tjia J, Lapane K (2017) Guideline-based prescribing in frail elderly patients. JAMA Intern Med
177(2):262–263
Tolson D, Rolland Y, Andrieu S, Aquino J-P et al (2011) International Association of Gerontology
and Geriatrics: a global agenda for clinical research and quality of care in nursing homes. J Am
Med Dir Assoc 12:184–189
Trautinger F (2001) Mechanisms of photodamage of the skin and its functional consequences for
skin ageing. Clin Exp Dermatol 26(7):573–577
Turnheim K (1998) Drug dosage in the elderly. Is it rational? Drugs Aging 13(5):357–379
van Assema DM, Lubberink M, Boellaard R, Schuit RC, Windhorst AD, Scheltens P, Lammertsma
AA, van Berckel BN (2012) P-glycoprotein function at the blood-brain barrier: effects of age
and gender. Mol Imaging Biol 14(6):771–776
van der Lee MJ, Blenke AAM, Rongen GA, Verwey-van Wissen CPWGM, Koopmans PP,
Pharo C, Burger DM (2007) Interaction study of the combined use of paroxetine and
fosamprenavir-ritonavir in healthy subjects. Antimicrob Agents Chemother 51(11):4098–4104
Vemuri R, Gundamaraju R, Shastri MD, Shukla SD, Kalpurath K, Ball M, Tristram S, Shankar EM,
Ahuja K, Eri R (2018) Gut microbial hanges, interactions, and their implications on human
lifecycle: an ageing perspective. Biomed Res Int 2018:4178607. 1–13
15
The Importance of Drug Dose Adjustment in Elderly Patients with Special. . .
271